Improvement of metabolic syndrome reduces the risk of kidney stone

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861291
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Wakayama Medical University
• Principal Investigator: Iba Akinori 和歌山県立医科大学, 医学部, 助教 (00423939)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 尿路結石症 / メタボリックシンドローム

Outline of Final Research Achievements

According to the types of stone composition, the severity of urolithiasis and abnormalities in urine constituents were examined by the number of metabolic syndrome (MetS) traits (obesity, hypertension, dyslipidemia, and diabetes) using clinical data from patients with urolithiasis enrolled in the 6th Nationwide Survey on Urolithiasis in Japan conducted in 2005. In patients with calcium oxalate (CaOx) stone, MetS trait clustering is associated with greater severity of the disease and increased urinary calcium excretion. These results suggest that CaOx stone disease should be regarded as a systemic disorder linked to MetS. Improvement of MetS was thought to have the potential to prevent CaOx stone, which accounts for most of urolithiasis. I presented these results at American Urological Association 2017 and am submitting a paper. Indeed, for obese patients, we planned to examine whether weight loss prevents urolithiasis, but we are recruiting obese patients because of lack of cases.

Free Research Field

泌尿器科学