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2016 Fiscal Year Final Research Report

The role of perioperative circulating tumor cell in patients undergoing prostate radiotherapy

Research Project

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Project/Area Number 26861293
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionKitasato University

Principal Investigator

Tsumura Hideyasu  北里大学, 医学部, 助教 (20348569)

Research Collaborator SATOH Takefumi  
TABATA Ken-ichi  
ISHIYAMA Hiromichi  
NAKAMURA Masaki  
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords前立腺癌 / 放射線治療 / 密封小線源療法 / 血中循環腫瘍細胞 / 医原性播種 / 血行性転移
Outline of Final Research Achievements

Despite the absence of local prostate cancer recurrence, some patients develop distant metastases after prostate brachytherapy. We evaluate whether prostate brachytherapy procedures have a potential risk for hematogenous spillage of prostate cancer cells. While no preoperative samples showed circulating tumor cells (CTCs) (0%), they were detected in intraoperative samples in 7 of the 59 patients(11.8%). We detected CTCs from samples immediately after the surgical manipulation. Further study is needed to evaluate whether those CTCs actually can survive and proliferate at distant sites.

Free Research Field

前立腺癌

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Published: 2018-03-22  

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