2016 Fiscal Year Final Research Report
The role of perioperative circulating tumor cell in patients undergoing prostate radiotherapy
| Project/Area Number |
26861293
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Research Collaborator |
SATOH Takefumi
TABATA Ken-ichi
ISHIYAMA Hiromichi
NAKAMURA Masaki
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 前立腺癌 / 放射線治療 / 密封小線源療法 / 血中循環腫瘍細胞 / 医原性播種 / 血行性転移 |
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| Outline of Final Research Achievements |
Despite the absence of local prostate cancer recurrence, some patients develop distant metastases after prostate brachytherapy. We evaluate whether prostate brachytherapy procedures have a potential risk for hematogenous spillage of prostate cancer cells. While no preoperative samples showed circulating tumor cells (CTCs) (0%), they were detected in intraoperative samples in 7 of the 59 patients(11.8%). We detected CTCs from samples immediately after the surgical manipulation. Further study is needed to evaluate whether those CTCs actually can survive and proliferate at distant sites.
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| Free Research Field |
前立腺癌
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