2017 Fiscal Year Final Research Report
The study of TF expression and hypercoagulability in the gynecologic malignant tumor
| Project/Area Number |
26861310
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 婦人科悪性腫瘍 / 静脈血栓塞栓症 / Tissue factor(組織因子) |
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| Outline of Final Research Achievements |
Venous Thromboembolism develops before the start of treatment in about 25% of patients with ovarian cancer. Tissue factor (TF), initiates extrinsic blood coagulation. We investigated the intensity of TF expression (ITFE) and VTE in 128 patients with epithelial ovarian cancer. Before starting treatment, all patients were ultrasonographically screened for VTE. The ITFE was graded based on immunostaining of surgical specimens. The prevalence of VTE was significantly higher in CCC (34%) than in non-CCC (17%, P= 0.03). As ITFE increased, the frequencies of CCC and VTE increased significantly (P<0.001 and P=0.014, respectively). Multivariate analysis identified TF expression and pretreatment D-dimer level as significant independent risk factors for VTE development. Expression of TF is high in CCC significantly, and involved in the development of VTE.
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| Free Research Field |
婦人科悪性腫瘍
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