2015 Fiscal Year Final Research Report
Creation of the model of multistep carcinogenesis derived from ovarian endometrioma by introducing defined genetic elements
| Project/Area Number |
26861317
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa University |
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Principal Investigator |
Bono Yukiko 金沢大学, 大学病院, 助教 (80565416)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 子宮内膜症 / 卵巣がん / 癌化 |
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| Outline of Final Research Achievements |
Ｍalignant transformation of endometriotic epithelial cells required overexpression of c-myc or phospho-Akt or mutation of PIK3CA in addition to dysfunctional p53 and mutated KRAS. Since overexpresison of phospho-Akt or mutation of PIK3CA lead to activate c-Myc by its phosphorylation, c-Myc activation in ovarian endometrioma might play a key role in transformation in the presence of dysfunctional p53 and activated ERK pathway.
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| Free Research Field |
産婦人科
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