Central control mechanism of reproductive regulatory hormones

2017 Fiscal Year Final Research Report

• Project/Area Number: 26861327
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Shimane University
• Principal Investigator: Oride Aki 島根大学, 医学部, 講師 (00423278)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: GnRH / 視床下部 / キスペプチン

Outline of Final Research Achievements

GnRH neurons certainly play a pivotal role in the Hypothalamic-Pituitary-Gonadal axis. gonadotropins( luteinizing hormone (LH) , follicle-stimulating hormone (FSH)) are primarily controlled by GnRH, which is released from the hypothalamus. Recently, it is now recognized that kisspeptin acts upstream of GnRH and can stimulate gonadotropin release from the pituitary gland by stimulating GnRH release. Nevertheless, the detailed mechanisms underlying the regulation of homogeneous populations of GnRH neurons are still largely unknown. In this study, we describe in vitro studies using a GnRH-producing cell model, GT1-7 cells, which have been used to examine how GnRH-producing cells respond to hypothalamic factors and how they are involved in GnRH synthesis.
GnRH and kisspeptin are expressed not only in hypothalamic neurons but also in a number of peripheral organs. In this study, we examined how these peptides are regulated within the placenta.

Free Research Field

生殖内分泌