2016 Fiscal Year Final Research Report
microRNA is involved in the pathogenesis of endometriosis.
| Project/Area Number |
26861336
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Oita University |
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Principal Investigator |
ABE WAKANA 大分大学, 医学部, 病院特任助教 (30457618)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 子宮内膜症 / エピジェネティクス |
|---|
| Outline of Final Research Achievements |
Utilizing miRNA microarray analysis, we found 8 downregulated miRNAs and 4 upregulated miRNAs in cultured ECSCs. Compulsory expression of miR-503 directed the inhibition of cell proliferation and the induction of apoptosis in ECSCs. miR-503 was found to suppress the mRNA expression of Bcl-2, VEGF-A and Cyclin D1 in ECSCs.
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| Free Research Field |
産婦人科学
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