2017 Fiscal Year Final Research Report
Prognostic and contributory factor of one fetal growth restriction in dichorionic diamniotic twin pregnancy
| Project/Area Number |
26861339
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Research Collaborator |
INO Kazuhiko 和歌山県立医科大学, 医学部, 教授
NANJO Sakiko 和歌山県立医科大学, 医学部, 客員研究員
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 2絨毛膜性2羊膜性双胎 / 胎児発育不全 / 酸化ストレス |
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| Outline of Final Research Achievements |
We focused that there were same maternal uterine enviroment in dichorionic diamniotic twin, which had no anastomoses of vessels between two fetus in placenta. We studied perinatal outcome of one fetal growth restriction in dichorionic diamniotic twin pregnancy and valued the level of d-ROMs in the serum of umbilical cord vein. We defined "severe FGR" as under -2.0SD of the gestational age at delivery. In severe SGA group, the proportion of adverse prognosis of smaller twin was statistically higher than larger twin. In the analysis of the serum level of d-ROMs in umbilical cord vein, smaller twin of severe SGA group was higher than larger twin, but not statistically significant. In one fetal growth restriction in dichorionic diamniotic twin, the result of our study suggested that smaller twin of severe SGA was under oxidant stress and it lead to the possibility of adverse prognosis.
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| Free Research Field |
産科婦人科学、周産期医学
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