2016 Fiscal Year Final Research Report
Mechanism of follicle development using CNP on aging mice
| Project/Area Number |
26861346
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
YORINO SATO 聖マリアンナ医科大学, 医学部, 研究技術員 (00511073)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 卵胞発育 / aging |
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| Outline of Final Research Achievements |
Follicle growth is necessary follicle stimulate hormone. However FSH low responder or aging woman patients resist follicle growth by FSH stimulation. We found CNP induce follicle development acting through cGMP increasing under FSH. In this study, we identified candidate of CNP downstream and clarified molecular mechanism of follicle development. Furthermore, we evaluated oocyte quality of aging model mice.
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| Free Research Field |
生殖医学
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