The role of SIRT6 protein in gynecologic cancer.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861348
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Research Institute for Clinical Oncology, Saitama Cancer Center
• Principal Investigator: Miyamoto Yuichiro 埼玉県立がんセンター(臨床腫瘍研究所), その他部局等, その他 (70634955)
• Co-Investigator(Kenkyū-buntansha): SAKURABASHI Ayako 東京大学, 大学院医学系研究科 生殖・発達・加齢医学, 大学院生 ; FUKUDA Tomohiko 東京大学, 大学院医学系研究科 生殖・発達・加齢医学, 大学院生 (40433510)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 子宮体癌 / SIRT6 / サバイビン / YM155

Outline of Final Research Achievements

The NAD-dependent deacetylase SIRT6 is participated in cancer metabolism and thought to be one of the molecular target in the treatment of the endometrial cancer.
The overall survival rate is preferable in SIRT6 overexpression group than underexpression group in our endometrial cancer clinical specimen. Moreover, SIRT6 protein induced cell death in endometrial cancer cell lines, via suppression the expression of survivin, which is an apoptotic related protein and the putative target of cancer therapy. We revealed the Survivin inhibitor YM155 prevent the cell growth of endometrial cancer. From these results, the inhibition of Survivin protein function via SIRT6 is supposed to be the putative target of endometrial cancer treatment.

Free Research Field

婦人科腫瘍学