2016 Fiscal Year Final Research Report
Effect of epigenomic mutation on preimplantation development
| Project/Area Number |
26861350
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
Fukuda Atsushi 国立研究開発法人国立成育医療研究センター, 細胞医療研究部, 研究員 (00638091)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 初期胚 / 生殖細胞 / エピジェネティクス |
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| Outline of Final Research Achievements |
Using mouse embryos as model for studying the effect of epigenomic mutations on embryonic development, the embryos with alteration of epigenetic states were produced using mRNA overexpression and treatment of small molecule. These treatments caused maternal Xist derepression in preimplantation stages. Moreover, using these system, we demonstrated that the female lethality in Xist paternal deleted embryos could be rescued. These results provide new insight into reproductive medicine.
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| Free Research Field |
エピジェネティクス
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