Replication study of candidate genes associated with Age-Related Hearing Impairment in the Japanese population

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861366
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Shinshu University
• Principal Investigator: SUZUKI Nobuyoshi 信州大学, 医学部附属病院, 医員 (20377641)
• Co-Investigator(Renkei-kenkyūsha): USAMI Shin-ichi 信州大学, 学術研究院医学系, 教授 (10184996) ; NISHIO Shin-ya 信州大学, 学術研究院医学系, 助教 (70467166)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 遺伝子 / 老人性難聴 / SNP / 候補遺伝子関連解析

Outline of Final Research Achievements

Age-related hearing impairment (ARHI) or presbycusis is the most common sensory neural impairment in the elderly. Several genes have been reported as susceptibility genes for ARHI in the European population: GRHL2, NAT2, GRM7 and IQGAP2, and in the Japanese population: MTHFR and MTR. We tried to replicate previously reported associated SNPs in Age related hearing loss. We tried to replicate previously reported associated SNPs in 620 samples from a Japanese population, aged 50-75 years. None of the previously found SNPs showed significant associations with ARHI in our Japanese population. Until now, all previous association results remain un-replicated. ARHI is a highly complex disorder, involving many variants with small effect sizes, which require larger studies with more power.

Free Research Field

耳鼻咽喉科学