2015 Fiscal Year Final Research Report
The function of Tis21 gene at development of the cochlea
Project/Area Number |
26861396
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Otorhinolaryngology
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Research Institution | Kumamoto University |
Principal Investigator |
Kusaba Yuki 熊本大学, 医学部附属病院, 医員 (70648592)
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Co-Investigator(Renkei-kenkyūsha) |
MINODA Ryosei 熊本大学, 大学院生命科学研究部, 准教授 (30284772)
YAMADA Takao 熊本大学, 医学部付属病院, 医員 (90573593)
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Research Collaborator |
TAKEDA Hiroki 熊本大学, 大学院耳鼻咽喉科・頭頸部外科学, 大学院生
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Keywords | Tis21 / 聴覚 |
Outline of Final Research Achievements |
We purchased Tis21 deficient mice from Jackson Laboratory ( the United States ) , underwent immunostaining and in situ hybridization, which examined the expression of Tis21 protein in embryonic inner ear . Morphological assessment of Tis21 deficient mice in the future ( cochlea form , the number of cochlear hair cells , spiral ganglion cell numbers , etc.) carried out , which is scheduled to be examined pathology of dysfunction . In addition , with respect to the context of the gene , such as Ngn1, NeuroD, Atoh1 and are involved in inner ear development , it is expected to examine using, for example, immunostaining.
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Free Research Field |
聴覚
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