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2015 Fiscal Year Final Research Report

Role of Interferon reguratory factor for distal metastasis in head and neck cancer

Research Project

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Project/Area Number 26861408
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionYokohama City University

Principal Investigator

TAKAHASHI Hideaki  横浜市立大学, 附属病院, 助教 (50727196)

Project Period (FY) 2014-04-01 – 2016-03-31
Keywords頭頸部癌 / 肺転移 / IRF
Outline of Final Research Achievements

This study evaluated the correlations the invasion ability and the migration ability and IRF in head and neck squamous cell carcionoma cell lines. siRNA knockdown of IRF1, 2, 6 and over expression of IRF1, 2, 6 with IRFs vector in metastatic HNSCC cells did not suppress tumor invasion and migration. But, over expression of IRF1, 2, 6 with IRFs vector in metastatic HNSCC cells promote cell proliferation.

Free Research Field

耳鼻咽喉科学

URL: 

Published: 2017-05-10  

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