Involvement of macrolide-resistant staphylococci in chronic sinusitis difficulty

2017 Fiscal Year Final Research Report

• Project/Area Number: 26861424
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Kawasaki Medical School
• Principal Investigator: HYO YUKIYOSHI 川崎医科大学, 医学部, 講師 (80412203)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ブドウ球菌 / マクロライド / 形態変化 / エアロゾル療法

Outline of Final Research Achievements

Rhinosinusitis is a common disease, but it is a disease that is often improved by administration of penicillin antibiotics or macrolide antibiotics in general. Especially in Japan, it is often improved by administering a small amount of macrolide antibacterial drug for a long period to chronic rhinosinusitis. On the other hand, there are cases where improvement is not achieved by such a treatment method, and these cases are often referred to as refractory. Especially it has been said that eosinophilic sinusitis, which became difficulty designation, has involvement of staphylococci.
Therefore, we carried out a study to see if the pathological condition exerting macrolide tolerance-induced morphological change plays a role in refractory.

Free Research Field

鼻科学