2016 Fiscal Year Final Research Report
Analysis on corneal tissue after autologous cultivated oral mucosal epithelial cell sheet transplantation
Project/Area Number |
26861448
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Ophthalmology
|
Research Institution | Osaka University |
Principal Investigator |
Oie Yoshinori 大阪大学, 医学系研究科, 助教 (20599881)
|
Research Collaborator |
KOH Shizuka
HASHIDA Noriyasu
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 眼発生・再生医学 |
Outline of Final Research Achievements |
Corneal epithelium and stroma was evaluated for 4 patients who underwent keratoplasty following cultivated oral mucosal epithelial cell sheet transplantation. Stem cells were maintained in the basal layer more than one year after transplantation. In one case, keratin 12 specific for corneal epithelium was positive. It was suggested that cultivated oral mucosal cells obtained corneal phenotype in consequence of surrounding environment. Also, MUC16 specific for ocular surface was positive in three cases.
|
Free Research Field |
医歯薬学
|