2015 Fiscal Year Final Research Report
Investigation and new therapeutic strategy for the hyperpermeability of the diabetic retinal vessels
| Project/Area Number |
26861454
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University |
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Principal Investigator |
Arita Ryoichi 九州大学, 大学病院, その他 (30621289)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 血管透過性亢進 / 糖尿病網膜症 / Rho kinase |
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| Outline of Final Research Achievements |
Diabetic macular edema is well-known ocular complication and the leading cause of poor visual impairment in diabetes. Diabetic macular edema beaks down the blood-retinal barrier, leading to fluid leakage from abnormal retinal capillaries.
This study investigates that ROCK plays a significant role for barrier functions of vascular permeability. ROCK inhibitor recovered diabetes-induced barrier disruption and vascular hyperpermeability. These data indicates ROCK inhibitor has the ameliorating effect on diabetes-induced macular edema via blockade of vascular permeability.
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| Free Research Field |
糖尿病網膜症
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