2015 Fiscal Year Final Research Report
The effect of periocularly administered candesartan-PLGA microparticles on diabetes-induced retinal inflammatory damage
| Project/Area Number |
26861474
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 糖尿病網膜症 / 局所投与 / PLGA |
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| Outline of Final Research Achievements |
The purpose of this research was to determine whether periocular candesartan, an angiotensinII typeI receptor antagonist, -poly(lactic-co-glycolic acid : PLGA) microparticles alleviate diabetes-induced inflammation in Sprague Dawley rats. Treatment with periocularly administered candesartan-PLGA microparticles significantly decreased the permeability of the retinal microvessels. The number of adherent leukocytes was significantly reduced, together with retinal VEGF, ICAM-1 and MCP-1 in the diabetic+candesatan group compared with the diabetic group. The periocular administration of candesartan-PLGA microparticles inhibit diabetes-induced retinal inflammatory damage, indicating their potential usefulness in treating diabetic retinopathy.
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| Free Research Field |
眼科
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