The development of fetal therapy in model of congenital diaphragmatic hernia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861485
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatric surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Sakai Kohei 京都府立医科大学, 医学(系)研究科(研究院), 助教 (30515292)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 先天性横隔膜ヘルニア / nitrofen / 胎児治療 / bombesin

Outline of Final Research Achievements

Congenital diaphragmatic hernia (CDH) is a disease that has a still high mortality rate among neonatal surgical diseases. In our facility, intensive care based on gentle vetilation gained marked improvement in survival rate. However, patients who have severe pulmonary hypoplasia can not be rescued. In order to develop fetal therapy for severe cases, administration of neuropeptide bombesin to congenital diaphragmatic hernia model rat increased lung body weight ratio, decreased cell growth factor, type 2 alveolar epithelial cells Results leading to lung maturation such as reduction could be obtained. As for the effect of combined use with other drugs, it is impossible to obtain sufficient results and it is a future subject.

Free Research Field

小児外科