2016 Fiscal Year Final Research Report
Botox injection to improve compliance in the compromised fetal bladder.
| Project/Area Number |
26861489
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pediatric surgery
|
|---|
| Research Institution | St. Marianna University School of Medicine |
|---|
Principal Investigator |
Nagae Hideki 聖マリアンナ医科大学, 医学部, 助教 (90468942)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | Botulin / Fetal / Surgery / Toxin |
|---|
| Outline of Final Research Achievements |
A recent development has been the use Botulin Toxin(BTX) to treat bladder dysfunction. In our experiment, a vesico-amniotic (VAS) shunt in a normal fetal lamb bladder produces a thick-walled, poorly-compliant bladder. BTX improves compliance in neurogenic bladders. We tried BTX in our VAS model.
We placed non-valved VAS in 80-day gestation fetal lambs, injecting BTX (10units/kg) at 100 days at 4 sites around the shunt (Group A). They were delivered at term (145 days) and bladder volume, histology were measured.BTX injected into a compromised bladder at 100 days were able to improve a survival rate, but doesn’t improve compliance at term.
|
| Free Research Field |
医歯薬学
|
