Development and application of bioimaging technology to contribute to the spatiotemporal and functional analysis in inflammatory miRNA

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861503
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Nagasaki University
• Principal Investigator: TANAKA Katsuya 長崎大学, 病院(医学系), 医員 (70722750)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: miRNA / 炎症 / イメージング / 皮膚創傷治癒 / 炎症細胞

Outline of Final Research Achievements

This study has been performed to elucidate the organizational and molecular correlation influencing on tissue repair mechanism including scar formation by spatiotemporal dynamics of inflammatory cells at skin wound. And we achieved to identify the skin wound inflammation-related microRNA (miRNA) which was noted having various functions. Furthermore, we produced the miRNA knockout mice and revealed that the one of inflammation-related miRNA affected the phagocytosis and infection control function of neutrophils having a central role in innate immunity by using bioimaging technique. The imaging techniques used in this study that employed a confocal fluorescent microscope can be a technique that is widely used in the world.

Free Research Field

医歯薬学