Development of cranial bone regeneration method using combination of control-released platelet-rich plasma and osteoinductive materials

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861512
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Juntendo University
• Principal Investigator: SHIMIZU Azusa 順天堂大学, 医学部, 准教授 (00407272)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 多血小板血漿 / PRP / 徐放化 / 頭蓋骨再生 / β-TCP

Outline of Final Research Achievements

Cranioplasty for defects of the skull is generally performed with nonabsorbable materials or autologous bone. However, these materials are occasionally associated with complication such as infection and donor-site morbidities. Platelet-rich plasma(PRP) promotes wound healing and bone regeneration and its clinical use is rapidly spread. Therefore, we investigated whether a combination of PRP and β-TCP as biodegradable osteoinductive materials could be cut down for bone healing period. Our result also suggested that the slow and continuous release of growth factor from PRP can promote bone regeneration more powerfully, so this material can be safe and effective bone filler.

Free Research Field

頭蓋顎顔面外科