2015 Fiscal Year Final Research Report
A new therapeutic strategy by suppression of F-actin/DNGR-1 signal in a rat model of crush injury
| Project/Area Number |
26861521
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | クラッシュ症候群 / Fアクチン / DNGR１受容体 |
|---|
| Outline of Final Research Achievements |
The purposes of this study are as follows.①To investigate the F-actin/DNGR-1 signal in the context of systemic acute inflammation following crush injury and to assess the therapeutic effects of anti- F-actin antibody in a rat model of crush injury. ②To evaluate the F-actin/DNGR-1 signal in the patients with systemic inflammation (Trauma and Sepsis). In this study, the administration of anti-Factin antibody did not improve the 7-day survival rate of crush injury rat model. The circulating F-actin levels significantly increased in the patients with sepsis, suggesting that the signal play a role in the pathogenesis of sepsis.
|
| Free Research Field |
医歯薬学
|
