2015 Fiscal Year Final Research Report
Searching for biomarker to evaluate endothelial dysfunction after drug-eluting stent implantation
| Project/Area Number |
26861536
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | IL-1β / 薬剤溶出性ステント / 内皮機能障害 / mTOR |
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| Outline of Final Research Achievements |
Patients with mammalian target of rapamycin (mTOR)-inhibitor drug-eluting stent (DES) were reported to have impaired coronary endothelial function. There is no non-invasive biomarker of coronary endothelial dysfunction. Interleukin (IL)-1β is known to cause of endothelial dysfunction. We examined whether IL-1β were associated with coronary endothelial dysfunction after mTOR-inhibitor DES , and to investigate the possible mechanism.
Increased serum IL-1β could detect coronary endothelial dysfunction after DES implantation. mTOR inhibition triggers IL-1β release through transcriptional activation in CASMCs of stent site, which may lead to coronary endothelial dysfunction at distal to the stent.
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| Free Research Field |
心血管カテーテル治療学
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