2015 Fiscal Year Final Research Report
Efficacy and role of myocardial ischemic preconditioning via activate signaling pathway by SOCS3-CKO in myocardial ischemia repercussion injury
| Project/Area Number |
26861537
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | SOCS3 / JAK-STAT signaling / ischemia reperfusion / ischemic preconditioning |
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| Outline of Final Research Achievements |
I investigated the role of myocardial suppressor of cytokine signaling-3 (SOCS3), an intrinsic negative feedback regulator of the JAK-STAT signaling pathway, in the pathophysiology of myocardial ischemic preconditioning (IPC) and myocardial ischemia-reperfusion injury (IRI). Activation of STAT3 was rapidly peaked and was inactivated after IPC. The infarct size 24 hour after IRI was reduced in SOCS3-CKO. These results suggested that progression of myocardial IRI was prevented in SOCS3-CKO hearts. Cardiac-specific SOCS3 deletion enhanced cardioprotective signaling pathway by ischemic preconditioning.
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| Free Research Field |
循環器内科
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