2015 Fiscal Year Final Research Report
Investigation of network between cancer cells and osteocyte under circumstance of bone metastasis
| Project/Area Number |
26861539
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
YAMADA TAMAKI 北海道大学, 大学病院, 医員 (80580943)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 骨代謝 / 骨細胞 / FGF23 |
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| Outline of Final Research Achievements |
I focused attention on behavior of osteocytes in bone metastasis foci of cancer cells.Especially, I analyzed on network between osteocytes and cancer cells. I focused attention on FGF23, which is produced by osteocytes and involved in bone metabolism. FGF23 did not express in osteocytes, to which cancer cells metastasized. By contrast, FGF23 expressed abundantly in bone metastasis foci. From these results, I inferred the existence of network between osteocytes and cancer cells. These results showed that FGF23 expression had a lot of involvement in bone metastasis of cancer cells. I research if cancer cells express FGF23 by metastasizing to bone and have directivity to bone.
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| Free Research Field |
口腔外科
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