2016 Fiscal Year Final Research Report
Overcome the drug resistance by targeting tumor endothelial markers
| Project/Area Number |
26861540
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 腫瘍血管内皮細胞 / がん幹細胞 / 薬剤抵抗性 |
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| Outline of Final Research Achievements |
In this study, to identify tumor endothelial marker (TEC marker) that is involved in drug resistance, drug sensitivity to anti-cancer drug was analyzed using siRNA or inhibitor of TEC markers. The inhibitor of p-glycoprotein encoded by MDR-1 gene, enhanced sensitivity to paclitaxel, in vitro and in vivo. These results suggested that inhibition of TEC markers are possible strategy to overcome drug resistance.
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| Free Research Field |
腫瘍血管新生
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