2015 Fiscal Year Final Research Report
The role of microRNAs in lip and palate development.
| Project/Area Number |
26861545
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
KAWASAKI Maiko 新潟大学, 医歯学総合病院, 助教 (40584587)
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| Project Period (FY) |
2014-02-01 – 2016-03-31
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| Keywords | miRNA / 口蓋裂 / 口唇裂 |
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| Outline of Final Research Achievements |
The role of microRNAs in lip and palate development was investigated in this study. In order to examine microRNA function, we generated mice with mutation of Dicer, which is an essential molecule for microRNA processing. Mice with epithelial conditional mutation of Dicer exhibited no significant anomalies in the lip or palatal tissues. However, mice with neural crest-derived cell conditional mutation of Dicer showed clefting of the lip and palate, suggesting that microRNAs in neural crest-derived cells play a critical role in lip and palate development. The palatal cleft was found to be caused by failure of palatal shelf elevation, with defects in anterior mandible process formation leading to clefting of the lip.
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| Free Research Field |
口腔解剖学
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