2015 Fiscal Year Final Research Report
The role of pneumococcal beta-helix protein, PfbA, in the evasion from host innate immunity
| Project/Area Number |
26861546
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | Streptococcus pneumoniae / 肺炎球菌 / 抗貪食 / PfbA / 好中球 / 自然免疫回避 |
|---|
| Outline of Final Research Achievements |
In this study, we investigated the role of pneumococcal cell surface protein, PfbA, in the evasion from host innate immunity. Bioinformatic analysis showed that PfbA is a highly and specifically conserved protein in Streptococcus pneumoniae strains. In addition, our experimental results indicated that PfbA contributes to bacterial resistance to neutrophil killing via inhibiting its phagocytosis.
|
| Free Research Field |
細菌学
|
