2015 Fiscal Year Final Research Report
A Novel Mechanism of Osteo-network through MicroRNAs
| Project/Area Number |
26861548
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
Takei Yuichiro 広島大学, 医歯薬保健学研究院(歯), 助教 (10711377)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | マイクロRNA / 骨基質小胞 / 破骨細胞形成 |
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| Outline of Final Research Achievements |
The balance between bone formation and bone destruction is fundamental on the skeletal homeostasis.
We found the microRNAs (miRNAs) included in bone matrix vesicles (BMVs), that is specifically derived from bone-forming osteoblasts. Furthermore, it had been uncovered osteoblasts applied BMV as a signal transducer and suppressed the differentiation from macrophages into osteoclasts, bone-absorbing cells. Especially, it was suggested that a certain miRNA, miR-125b involved in BMVs was crucial in this pathway.
This study contributes a discovery of a novel mechanism of bone metabolism.
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| Free Research Field |
形態系基礎歯科学
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