2016 Fiscal Year Final Research Report
Endocrine functions of osteocalcin
| Project/Area Number |
26861553
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | オステオカルシン / 性差 / アディポネクチン / テストステロン / 糖代謝 |
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| Outline of Final Research Achievements |
Osteocalcin, in its uncarboxylated form (GluOC), regulates energy metabolism by stimulating insulin secretion, pancreatic β-cell proliferation, and adiponectin expression in the adipocytes. In this study, we showed that there is a sex difference in the effect of GluOC on glucose homeostasis in mouse models. Long-term oral administration of GluOC improved glucose tolerance and decreased adipocyte size in female mice. However, the same treatment caused glucose intolerance, insulin resistance, and adipocyte hypertrophy in male mice. In addition, such administrations of GluOC increased circulating testosterone (T) and decreased serum adiponectin level. These phenotypes disappeared when mice were orchidectomized, and restored again by T supplementation. Moreover, female mice supplemented with T exhibited similar responses to GluOC as male mice. These results suggest that deleterious effect of GluOC is mediated in part by increased circulating T level.
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| Free Research Field |
生化学
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