2015 Fiscal Year Final Research Report
Research for treating or preventing pneumococcal pneumonia
| Project/Area Number |
26861570
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 肺炎球菌 / 好中球 / エラスターゼ / 免疫回避 |
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| Outline of Final Research Achievements |
Streptococcus pneumoniae is a Gram-positive bacterium that is a leading cause of bacterial pneumonia. It was suggested that excessively activated neutrophils release proteinases such as elastase that contribute to lung injury in severe pneumonia. However, underlying mechanisms are not fully understood. In this study, we investigated the effects of pneumococcal pneumolysin against neutrophils. Our findings suggest that S. pneumoniae induce neutrophil cell death caused by pneumococcal autolysis and subsequent release of pneumolysin and may trigger neutrophil elastase-dependent lung injury.
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| Free Research Field |
微生物学
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