2017 Fiscal Year Final Research Report
BNCT controls the life and death mechanisms of cancer cells.
| Project/Area Number |
26861571
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nara Medical University (2015-2017)
Kyoto University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | BNCT / BPA / 5-FU / ICP / 細胞周期 |
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| Outline of Final Research Achievements |
With neutron radiation after using boron pharmaceuticals（BPA) or X-ray, we collected foundational data, such as the survival rate curve. The relative biological effectiveness (RBE) from the survival rate curve to D10 was from approximately 2.5 to 3.0. Additionally, when we analyzed fluctuations in the cell cycles after irradiation, when isodose 2Gy irradiation was performed, in the neutron radiation group, it was recognized that the cell cycle stopped in the G2/M.
Next, with the transplantation-based animal experiments, an attempt was made to elucidate what cause existing BPA to accumulate in the tumor, and factors to prevent such accumulation. No significant difference was noted in the normal tissue of either group, but in the group to which 5-FU was administered to cancer tissue and 3 days later BPA was administered, a significant decrease in the absorption of boron was recognized.
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| Free Research Field |
外科系歯学
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