2016 Fiscal Year Final Research Report
The role of gingipains from P. gingivalis on host cell responses
| Project/Area Number |
26861573
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 歯周病原細菌 / ジンジパイン / 細胞内シグナル伝達 / PI3K/Akt経路 |
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| Outline of Final Research Achievements |
Peridontal diseases are chronic oral bacterial infectious diseases which indicate inflammation of periodontal tissues, alveolar bone loss, and, leading to loss of tooth. In this research, Porphyromonas gingivalis, which is one of the most major oral pathogens, produces cysteine proteases called as gingipains. The gingipains attenuate PI3 kinase/Akt signaling pathway, and Akt downstream proteins, which are mTOR, GSK3, Bad, PRAS40, and MDM2, are also altered the their level of phosphorylation by gingipains in gingival epithelial cells. Taken together, their activity is disturbed by gingipains in parallel with inactivation of PI3K/Akt.
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| Free Research Field |
細菌学
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