2015 Fiscal Year Final Research Report
A study of targeting therapy for MDSC in oral cancer.
| Project/Area Number |
26861576
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Yokohama City University |
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Principal Investigator |
SATO Yuki (立石有紀) 横浜市立大学, 医学(系)研究科(研究院), 客員研究員 (60573277)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 口腔癌 / 分子標的薬 / MDSC |
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| Outline of Final Research Achievements |
At first, we used 4T1 breast cancer mouse model, because mouse oral squamous cell cancer cells, SCC-7 was not able to established the tumor in mice. We observed expression of IL-13Ra2 in MDSCs isolated from 4T1 tumor moice. MDSCs, CD11b(+)Gr-1(+) sorted from mice splenocytes were highly expressing IL13Ra2 compared to CD11b(-)Gr-1(-) cells by FACS analysis. Then, we found that IL13-PE, targeting for IL-13Ra2, could directly kill MDSCs. It was suggested that targeting therapy for IL13Ra2 may be useful to eliminate not only tumor, but also MDSCs.
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| Free Research Field |
癌免疫学
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