Maxillofacial bone regeneration with osteogenic matrix cell sheets: An experimental study in rats

2017 Fiscal Year Final Research Report

• Project/Area Number: 26861680
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Nara Medical University
• Principal Investigator: Masahiko Maeda 奈良県立医科大学, 医学部, 研究員 (80453166)
• Research Collaborator: KIRITA Tadaaki ; YAGYUU Takahiro ; OHGUSHI Hajime ; AKAHANE Manabu ; UEYAMA Yoshihiro ; IMADA Mitsuhiko
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 細胞シート / ヒト間葉系幹細胞 / 顎骨欠損

Outline of Final Research Achievements

Cell sheets prepared from rat bone marrow-derived stromal cells were implanted into the rat mandibular symphysis; the result s indicated the usefulness of maxillofacial bone regeneration. Next, cell sheets prepared from human bone marrow-derived str omal cells were implanted into the mandibular symphysis of immunodeficient rats; however, bone formation was not clear. Then , we subcutaneously implanted artificial bone into the immunodeficient rats. Although the therapeutic effect was limited, we confirmed the osteogenic capacity of these cell sheets. Thus, we gained insights into developing new approaches for maxillo facial regeneration using cell sheets from human bone marrow-derived stromal cells and artificial bone.

Free Research Field

再生医療