2015 Fiscal Year Final Research Report
Regulatory mechanism of bone differentiation by Wnt inhibitory factor
| Project/Area Number |
26861686
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
onodera shoko 東京歯科大学, 歯学部, 助教 (90637662)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 骨芽細胞分化 / Wnt経路 / 歯根膜細胞 |
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| Outline of Final Research Achievements |
In this study,we focused on the relationship between WNT signaling pathway, especially WNT inhibitors, and osteoblasts to elucidate the mechanism of BMP related osteoblast differentiation.Osteoblast differentiation using human periodontal ligament fibroblasts hPDLF was suggested that one of the inhibitor of WNT pathway sclerostin worked strongly in bone formation. Sclerostin is expected as a therapeutic agent for bone formation from being a target of osteoporosis.
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| Free Research Field |
生化学
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