2015 Fiscal Year Final Research Report
The role of tumor endothelial cell derived factors in the formation of premetastatic niche
| Project/Area Number |
26861698
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
MAISHI Nako 北海道大学, 遺伝子病制御研究所, 助教 (00632423)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 腫瘍血管内皮細胞 / 転移 |
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| Outline of Final Research Achievements |
In this study, we investigated the role of tumor endothelial cells (TECs) in tumor metastasis. We focused on Gene X which is upregulated in TECs and is known to be involved in cell migration. We found that Gene X is involved in TEC migration and tube formation. In addition, TEC-derived molecule X was important for tumor cell migration. We examined the expression of molecular X in human clinical samples. Molecular X was expressed in tumor blood vessels of renal cancer, colon cancer and hepatocellular carcinoma. These data suggest that our finding in mouse tumor model may apply to human clinical cases.
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| Free Research Field |
血管生物学
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