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2017 Fiscal Year Final Research Report

Molecular Mechanisms in Osteoblast and Osteocyte Related with Drug Induced Osteonecrosis of the Jaws

Research Project

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Project/Area Number 26861717
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

MIYAGAWA KAZUAKI  大阪大学, 歯学部附属病院, 医員 (50635381)

Project Period (FY) 2014-04-01 – 2018-03-31
Keywords骨細胞 / 骨芽細胞 / ビスフォスフォネート / 抗RANKL抗体 / 顎骨壊死
Outline of Final Research Achievements

Bisphosphonate (BP) and anti-RANKL antibody are widely used as anti-resorptive agents for bone metastasis and osteoporosis. Although these agents have different effect mechanism, thay can sometimes result in osteonecrosis of the jaw (ONJ). We examined that these agents were different influence for the bone formation by osteocyte and osteoblast in long bones. This was evident in ovariectomized C57BL/6J mice, which were treated with zoledronic acid (ZOL) or anti-RANKL antibody. Bone mass in long bone of both mice groups treated with ZOL and anti-RANKL antibody under lack of estrogen had significantly increased compared to control mice. Additionally, the changes in the expression of bone formation-related genes (Sost, Dmp1, and Osteocalcin) in long bones of mice treated with either ZOL or anti-RANKL antibody was different. Thus, these results suggested that the regulatory mechanisms of bone formation in osteocytes and osteoblasts differs between BP and anti-RANKL antibody.

Free Research Field

口腔外科学

URL: 

Published: 2019-03-29  

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