Development of combination chemotherapy using NF-kappaB as molecular target for oral cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861724
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: KANI Koichi 徳島大学, 病院, 助教 (60709583)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 臨床腫瘍学

Outline of Final Research Achievements

A marked antitumor effect was confirmed by using anti-cancer agent docetaxel and γ-tocotrienol of vitamin E in combination with oral cancer cell line B88 cells. In this study, we focused on NF-kappaB and examined it. That is, the combination of docetaxel and γ-tocotrienol suppressed NF-kappaB activity. Furthermore, it was thought that it induces apoptosis through inhibition of apoptosis inhibitory protein controlled by NF-kappaB and expression of apoptosis-related protein. Based on the findings obtained in this study, we would like to continue our research toward developing novel cancer chemotherapy.

Free Research Field

口腔外科学