2016 Fiscal Year Final Research Report
Development of combination chemotherapy using NF-kappaB as molecular target for oral cancer
Project/Area Number |
26861724
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
|
Research Institution | The University of Tokushima |
Principal Investigator |
KANI Koichi 徳島大学, 病院, 助教 (60709583)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 臨床腫瘍学 |
Outline of Final Research Achievements |
A marked antitumor effect was confirmed by using anti-cancer agent docetaxel and γ-tocotrienol of vitamin E in combination with oral cancer cell line B88 cells. In this study, we focused on NF-kappaB and examined it. That is, the combination of docetaxel and γ-tocotrienol suppressed NF-kappaB activity. Furthermore, it was thought that it induces apoptosis through inhibition of apoptosis inhibitory protein controlled by NF-kappaB and expression of apoptosis-related protein. Based on the findings obtained in this study, we would like to continue our research toward developing novel cancer chemotherapy.
|
Free Research Field |
口腔外科学
|