2016 Fiscal Year Final Research Report
Elucidation on the molecular mechanisms of the carcinogenesis and malignant transformation of oral cancer via DeltaNp63-mediated epithelial-mesenchymal transition
| Project/Area Number |
26861729
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ΔNp63 / 口腔扁平上皮癌 / 上皮-間葉転換（EMT） / KLK6 / miR-205 |
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| Outline of Final Research Achievements |
The purpose of this study is elucidation on the molecular mechanisms of the carcinogenesis, invasion, and metastasis of oral squamous cell carcinoma (OSCC) via DeltaNp63-mediated epithelial-mesenchymal transition (EMT).
As the results, it is suggested that downregulation of DeltaNp63 induced EMT in OSCC. Furthermore, DeltaNp63 regulates KLK6 and miR-205 regarded as EMT-related molecules, and therefore DeltaNp63 possibly involved in acquirement of the invasion, metastasis of OSCC.
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| Free Research Field |
医歯薬学
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