2017 Fiscal Year Final Research Report
Establishing of the a rat model of bisphosphonate-related osteonecrosis and development of novel treatment with teriparatide.
| Project/Area Number |
26861744
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | MRONJ / テリパラチド / 顎骨壊死 / LPS |
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| Outline of Final Research Achievements |
As a cause of the medication related osteonecrosis of the jaw bone (MRONJ), the participation of oral bacteria had been shown, but the possibility that the Lipopolysaccharide (LPS) of the gram-negative bacillus was the causes was shown in this study. In addition, it was only the animal model which assumed injectable BP patient, but succeeded in the development of the model rat which assumed internal use BP patient. In addition, the decrease in osteonecrosis area and the induced new bone formation were recognized by using teriparatide for MRONJ model rat. Usefulness of teriparatide for the treatment of MRONJ was shown.
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| Free Research Field |
歯科
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