2015 Fiscal Year Final Research Report
Anxiolytic actions of food intake : roles of activation of the PrRP neuron -oxytocin neuron pathway
| Project/Area Number |
26861747
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Research Collaborator |
ONAKA Tatsushi 自治医科大学, 医学部 生理学講座 神経脳生理学部門
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | オキシトシン / プロラクチン産生ニューロン / 摂食 / ストレス |
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| Outline of Final Research Achievements |
Food intake activated oxytocin neurones in the hypothalamus. Activation of oxytocin neurons in the hypothalamus in response to food intake was impaired in PrRP-deficient mice. Food intake facilitates peripheral CCK release.Peripheral administration of CCK activates oxytocin neurons. Activation of oxytocin neurons following peripheral CCK administration was also significantly reduced in PrRP-deficient mice. Oxytocin neurons have been shown to have anti-stress actions. Activation of the PrRP neuron-oxytocin neuron pathway following food intake may contribute to anxiolitic actions of food intake.
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| Free Research Field |
口腔外科
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