Establish of minimally invasive treatment method for neuropathic pain relief

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861758
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Osaka Dental University
• Principal Investigator: DAIGO Erina 大阪歯科大学, 歯学部, 助教 (50707073)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 神経障害性疼痛 / 半導体レーザー / 低出力レベルレーザー治療 / 疼痛緩和効果

Outline of Final Research Achievements

Low level laser treatment (LLLT) has been reported to have pain relief effect. Using inferior alveolar nerve injury in the rat (IANT) which developed neuropathic pain, this study verified the effectiveness of LLLT with semiconductor laser behaviorally and the expression of glial cells which play an important role in the onset of neuropathic pain immunohistologically. At the behavioral verification examination, the reduced of pain threshold was overserved in IANT, while the same trend wasn’t observed in LLLT-treated IANT. On the other hand, at the immuhistolocial examination, the expression of the cells were recognized to have increased in LLLT-treated IANT compared to IANT. From the above, it was concluded LLLT may have pain relief effect for neuropathic pain.

Free Research Field

歯科麻酔