Establishment of a differentiation method of periodontal ligament cells from human iPS cells, and development of dental implant with periodontal ligament.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861770
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Tohoku University
• Principal Investigator: KATO RYUSHI 東北大学, 歯学研究科(研究院), 助教 (90706699)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: iPS細胞 / 歯根膜

Outline of Final Research Achievements

The purpose of this study is establishment of a differentiation method of periodontal ligament (PDL) cells from iPS cells, which is generated by transfection of reprogramming genes in human PDL cells.
We first isolated human PDL cells. The PDL cells were transfected with plasmids for iPS cell generation. Three weeks after transfection, iPS cell-like colonies with clear edge were observed. In addition, we examined the experimental conditions with the aim of differentiation of the iPS cells into PDL cells.

Free Research Field

歯科矯正学