2015 Fiscal Year Final Research Report
The primary study of the role of the primary cilia in tongue development
| Project/Area Number |
26861779
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 舌 / 一次繊毛 |
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| Outline of Final Research Achievements |
In this study, we investigated the role of the primary cilia in tongue development. Mice with neural crest-derived cell conditional mutation of the primary cilia protein, Ofd1, showed notable tongue abnormalities, and the primary cilia were significantly shortened. However, mice with epithelium-, mesoderm- and endoderm-derived cell conditional mutation of Ofd1 exhibited no significant tongue abnormalities, suggesting that the primary cilia in neural crest-derived cells play a critical role in tongue development.
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| Free Research Field |
発生学
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