2015 Fiscal Year Final Research Report
Elucidation of the temporomandibular joint disease using a mechanical stimulus
Project/Area Number |
26861787
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthodontics/Pediatric dentistry
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Research Institution | Hiroshima University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Keywords | 変形性顎関節症 / ヒアルロン酸 / リモデリング / 潤滑機能 |
Outline of Final Research Achievements |
The temporomandibular joint osteoarthritis (TMJ-OA) is an inflammatory degenerative disease and that associated with the deformation of chronic arthritis ,Mandible jaw dysfunction, and causing the disharmony of facial appearance. Articular cartilage exerts buffering and lubricating functions when mechanical stress is applied to the joint surfaces during movement. However, the interaction between TMJ-OA and excessive mechanical stress still remains unclear. In this study, we focused on the pathogenesis of TMJ-OA,and to investigate the effect of HMW-HA on the expression of PRG4 and signaling pathway in cultured human fibroblast-like synoviocytes (HFLS).In conclusion, interaction between PRG4 and HA in articular cartilage may be critical for proper lubricating function on the surface of articular cartilage.Additionally, the use of purified HMW-HA and PRG4 formulations may be useful for the treatment of advanced OA.
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Free Research Field |
歯科矯正学
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