2016 Fiscal Year Final Research Report
Feeding-stimulating factor modulates synaptic transmission in the insular cortex
| Project/Area Number |
26861801
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
TAKEI Hiroki 日本大学, 歯学部, 助教 (50632543)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | オレキシン / 島皮質 |
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| Outline of Final Research Achievements |
Orexin and MCH are hormone that increase appetite. The insular cortex (IC) expresses these receptors. However almost no information is about the functional roles of these hormones in the IC. To explore this, I performed multiple whole-cell patch clamp recording in the rat IC slice preparation.Orexin A increased the amplitude of unitary inhibitory postsynaptic current (uIPSC) in fast-spiking neuron (FS) to pyramidal cell (Pyr) connections. Same as orexin A, I found that the amplitude of uIPSC in FS to Pyr was increased by orexin B. Pre-application of SB334867 that orexin receptor 1 antagonist diminished the orexin A/B-induced facilitation of uIPSC.
These result suggest orexin is likly to play a role in suppression of gustatory information processing in the IC.
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| Free Research Field |
小児歯科学
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