2016 Fiscal Year Final Research Report
Masticatory muscle plasticity in mouse
| Project/Area Number |
26861803
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthodontics/Pediatric dentistry
|
|---|
| Research Institution | Tsurumi University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 咀嚼筋 / シグナル伝達 / デキサメタゾン / 筋萎縮 |
|---|
| Outline of Final Research Achievements |
Masticatory muscles have the potential to adapt their mass and fiber types to a wide range of functional demands, as observed in limb muscles. However, these molecular mechanisms are poorly understood. In this study, we analyzed the effects of bite-opening treatment (BO) on muscle phenotypes of mice masseter muscle. To examine hypertrophic effects of BO on masseter and soleus muscles as well as antagonistic action of dexamethasone (DEX), a glucocorticoid, against hypertrophy, we analyzed both muscle mass and fiber diameter of masseter, soleus muscles in BO and/or DEX-treated mice. These results suggest that differences in the sensitivity to DEX or in the mechanisms of DEX antagonism between masseter and soleus muscles.
|
| Free Research Field |
歯科矯正学
|
