Elucidation of the molecular regulation mechanism of injury and recovery of periodontal tissue by orthodontic treatment

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861804
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Matsumoto Dental University
• Principal Investigator: Muraoka Rina 松本歯科大学, 歯学部, 助教 (20549430)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 歯周組織 / 歯根膜 / メカニカルストレス / 歯科矯正 / 修復 / リモデリング

Outline of Final Research Achievements

The purpose of the study was to determine the cell dynamics in periodontal ligament in response to mechanical stress during orthodontic movement. Mechanical stress during orthodontic movement promoted the increase in the number of cells in the periodontal ligament on both tension and pressure sides. The increase in the number of cells in the periodontal ligament is believed to be due to the migration and cell division of undifferentiated mesenchymal cells.
Also HSP47 is expressed in PDL fibroblasts on the compressed side damaged by application of mechanical stress and contributes to the repair of collagen tissue by activating PDL fibroblasts, supporting recovery from cell damage. HSP47 investigated in this study acts differently depending of the time of expression.

Free Research Field

歯科矯正学