Investigation into the roles of TRPV4 via mechanical stress in chronic periodontitis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861806
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Periodontology
• Research Institution: Meikai University
• Principal Investigator: SUZUKI TAKAFUMI 明海大学, 歯学部, 助教 (60638518)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: メカニカルストレス / 歯周病 / 骨

Outline of Final Research Achievements

To elucidate the molecular mechanism of occlusal trauma-induced alveolar bone resorption in chronic periodontitis, we focus on the roles of TRPV4 on the mechanical stress under chronic inflammation in osteoblasts. TRPV4 expression levels were increased during osteoblast differentiation. TRPV4-deficient osteoblast significantly suppressed shear stress-induced calcium oscillation. These results suggest that TRPV4 is involved in osteoblast differentiation via regulating intracellular calcium concentration.

Free Research Field

歯周病学